This clinical trial is sponsored by Moderna. Moderna is studying mRNA-1647, an investigational
vaccine, to understand whether it can help your immune system protect against cytomegalovirus (CMV).
The purpose of this clinical trial is to:
- Evaluate the safety and efficacy of investigational vaccine (a vaccine not yet approved by a country’s drug regulatory agency) mRNA-1647 against CMV
- Evaluate the safety of the vaccine in women who test positive to prior exposure to CMV
What is CMV?
Cytomegalovirus, shortened to CMV, is a leading cause of birth defects around the world. CMV is a common viral infection that usually goes unnoticed or only causes mild symptoms in most people. But if a woman becomes infected with CMV while she is pregnant, she can pass the infection to her unborn baby. This can cause her child to suffer long-term disability due to birth defects, including hearing loss, or even death in very severe cases. Currently, there is no approved vaccine against CMV.
CMV is the #1
infection that causes
birth defects in the
U.S. and one of the
infectious causes of
birth defects globally.
How Participation Works
The total length of participation in this clinical trial is
approximately 2½ years (30 months).
Get to Know the Investigational Vaccine: mRNA-1647
The investigational vaccine may help the body’s immune system recognize and protect itself if it comes into contact with CMV in the future. You cannot become infected with CMV from receiving the investigational vaccine. The investigational vaccine in this trial, mRNA-1647, is a newer type of vaccine known as an mRNA vaccine.
Every virus has signature features on its surface that can trigger your immune system. Once the features are mapped, an mRNA vaccine provides the blueprint to create the defense that can help your body protect itself if it encounters the virus.
Once your body has the blueprint, it knows exactly what to do. It reads mRNA strands to build a defense by producing antibody proteins that are a lot like the answer key to a test. This means the next time your immune system encounters this type of virus, it already has the answer to help protect you.
Your body now knows how to neutralize the virus and is able to defend itself against the threat if it encounters the virus in the future. The message from the blueprint that was read is retained and recalled when needed. It’s like remembering the answer from an old test without having to re-learn the material.
Moderna is developing mRNA vaccines, like the investigational vaccine mRNA-1647, that deliver blueprints to create the proteins that help activate immune responses against a variety of viruses.
About Clinical Trials
Vaccines aim to safely protect people against infections, and clinical trials are vital to creating vaccines. A clinical trial can help researchers understand whether an investigational vaccine is safe and effective. By participating in the CMVictory Trial, you can help create a future where we may hopefully declare victory and prevent the spread of CMV.
Moderna is committed to keeping people at the center of
everything we do as we continue to explore what is possible
through mRNA science. Without people like you, researching
potential new treatments and mRNA vaccines would not be possible.
We are proud to partner with the following groups and organizations in the fight for victory against CMV: